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Transcriptomic analysis demonstrated anti-inflammatory and anti-apoptotic effects were through MAPK pathway inhibition, showing inhibited phosphorylation of ERKs, JNKs, and p38 MAPKs with downstream upregulation of BCL2 and downregulation of Bax, CASP-3 and cytochrome (cyt) C [139]

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Thioctic acid, vitamin C (ascorbic acid) and glutathione

10.1038/s41467-017-02425-z 166 YangS.WangS.ChenL.WangZ.ChenJ.NiQ.et al (2023)

For platinum-resistant relapse, antibodydrug conjugates are redefining the landscape: in March 2024 the U.S

Burwinkel B, Kreuder J, Schweitzer S, Vorgerd M, Gempel K, Gerbitz KD, Kilimann MW: Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169Gln mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality