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Oxidative stress is found in amyloid deposits in systemic amyloidosis

10.1038/s41467-020-15798-5

Superoxide anions may directly react with NO, thereby stimulating the production of the NO/superoxide anion reaction product peroxynitrite (ONOO ), which in turn has been shown to uncouple the endothelial nitric oxide synthase (eNOS), thereby causing an anti-atherosclerotic NO-producing enzyme to become a ROS-producing enzyme, thus accelerating the atherosclerotic process

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Impact of iron overload by transfusion on survival and leukemia transformation of myelodysplastic syndromes in a single center of China

The major translational challenges include achieving sufficient tumor-specific accumulation over healthy tissues (especially for intravenous delivery), overcoming the heterogeneity and adaptability of the TME that may diminish catalytic efficacy, and addressing potential long-term toxicity of Pt accumulation