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10.1016/s0165-0173(02)00158-3 39 FranssonR.BotrosM.NybergF.LindebergG.SandstrmA.HallbergM

The classical metastatic cascade starts from a primary, epithelial, neoplastic lesion and includes: (1) epithelial mesenchymal transition (EMT) with a breach of the basement membrane barrier