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5 When ingested, the body must break it down into its active form before it can be used, which may be difficult for people with SNPs (genetic mutations) on B12 metabolic pathways

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[PMC free article] [PubMed] [Google Scholar] 391.Heldin CH

Early treatment with secukinumab even as a first-line systemic treatment became possible, not only according to label but also in daily practice

It means that excess amounts are typically excreted through urine rather than accumulating to toxic levels , making vitamin B12 supplementation generally safe even at higher doses, though adverse reactions such as hypersensitivity or acneiform rash can occur rarely