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Xiao YH, Chen DP, Yan JH, Yokoyama Y (2002) Mechanism of action of Tripterygium wilfordii polyglycoside on experimental endometriosis

(Source 1, 2) Glutathione levels decline with age and lower levels are associated with chronic diseases, including autoimmune diseases

By age 60, that concentration has fallen to approximately 80 ng/mL, a 60% decline that correlates directly with reduced healing capacity, collagen loss, and visible aging