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The ER provides an oxidizing environment, which promotes the protein folding and acts as a source of ROS (21)

The release of thyroid hormones T3 and T4 from the thyroid gland is stimulated by TSH

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The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations

Treatment options vary from topical drugs for minor conditions to systemic therapies and biologics for moderate-to-severe disease conditions