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This condition profoundly affects the quality of life of patients and imposes a significant socioeconomic burden (6)

10.1016/j.fct.2012.12.040 [DOI] [PubMed] [Google Scholar] 44

M.MillerT

This is in line with the recently revealed role of SYN as a critical mediator of inflammatory and immune responses ( Aside from PD models with direct injection of pSYN or SYN-PFF into the brain, there are also models based on peripheral injection of SYN-PFF