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2C, the protein expression levels of FOXO3a were decreased and p-FOXO3a were increased by L-carnitine treatment in a time-dependent manner, but the FOXO3a protein expression level was increased at 24 h

Johansen KL, Chertow GM, Jin C, Kutner NG

However, before discovering the necessity to carry out an insulin stimulus in order to increase muscle carnitine reserves, some studies [9,21,22] found lower accumulation of blood lactate concentration and an increase in O 2 and work capacity after oral l-C supplementation without insulin stimulus, particularly in high-intensity exercises [46,47]

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Interestingly, ETC function in fibroblasts from the CESLAC patients was almost opposite from the results from the muscle, with complex I activity being elevated rather than depressed