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In the CNS, both neurons and glial cells express cGAS and STING, and their activation by mtDNA has been directly implicated in neuroinflammation and NDDs [12, 93]

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Although single binary markers of senescence commitment have long been used in preclinical research, their utility as clinical parameters have so far been limited due to the wide-ranging heterogeneity of senescence in vivo , which often renders estimates of senescent cell quantification imprecise

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Levine, A., Zagoory-Sharon, O., Feldman, R., Lewis, J.G., and Weller, A (2007)