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Dose: SC injection of 250 g per injection in cats and, 250-1500 g per injection in dogs, depending on the size of the patient: *Information provided by Texas GI Lab* Northland Veterinary Services8560 Topper RoadIron River, WI 54847(715)372-5590

Published 2018 Aug 8

Landtblom and colleagues did a sophisticated meta-analysis that covered all studies from the period 1966-1994 and found 13 published studies

Complex neuropsychometric testing has hindered routine assessment of MHE and as such, there is little data on the overlap between MHE and frailty

In SOD1 mouse models, endplate denervation was seen prior to clinical weakness and motor neuron loss, suggesting that NMJ compromise occurs early in the pathophysiology of ALS and is often the inciting event prior to lower motor neuron injury (dying back hypothesis) [283]