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Description

Individuals with ASD exhibit dysregulated neuronal histone H3 lysine 4 (H3K4) methylation as well as upregulated histone deacetylase 4 (HDAC4) expression in the prefrontal cortex [92]

Siudeja, K

10.1101/gad.14.3.289 87 ShiehS

To access a fraction of that library in a proof-of-concept study, a 96-well assay containing ()- t -ES, Cp1B and Cp1D, eight proteinogenic amino acids (l-Ile, l-Leu, l-Val, l-Met, l-Phe, l-Trp and l-Tyr, with l-His as a negative control) and 12 amine donors including additionally tested amines such as spermidine ( b42 ), 4-(2-aminoethyl)-pyridine ( b43 ) and tryptamine ( b44 ) were performed