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As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy

Upon binding, ivermectin causes a prolonged phase of chloride ion influx, resulting in hyperpolarization, neuronal firing inhibition, paralysis, and ultimately, death of the parasite ( -aminobutyric acid (GABA)-gated chloride channel at higher concentrations, to further inhibit nervous system dysfunction in susceptible parasites (78)

Endocrine 73(3):609616

D., Wilson, F

ArcA then activates the tricarboxylic acid (TCA) cycle enzymes, leading to dysfunction of TCA cycle and the hyperactivation of respiration (Kohanski et al., 2008)

doi: 10.1038/sj.jhh.1001416 Vanderah TW (2024): Cholinoceptor-Blocking Drugs