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Concurrent activation of the ascorbateglutathione (AsA-GSH) cycle maintained redox equilibrium during early stress phases, though prolonged exposure imposed redox constraints

Biol Pharm Bull 34, 9296 (2011)

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In the dura mater and other regions supplied by the trigeminal nerve, this results in neurogenic inflammation due to excessive vasodilation, mast cell degranulation, plasma protein extravasation, and the release of inflammatory mediators such as serotonin