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PMCID: PMC2964977

10.1001/jamaophthalmol.2013.7677 63 JiL

Evidence suggests that Nurr1 and Pitx3 cooperate to regulate the expression of DA neurotrophic factors such as brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, as well as genes critical for DA neurotransmission, thereby promoting VTA DA neuron survival and the acquisition of mature DA phenotypes (Hegarty et al., 2013