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Wildtype Kir6.2 and 205-228a mutants were introduced into the intestines of Kir6.2 F/F mice through the Rosa26 - LSL system, similar to the method used for the GCK mutants

An RCT investigated the effect of 5 mg/d folic acid, the combination of 5 mg/d folic acid and 80 mg/d pyridoxin, and placebo for 3 months

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Indeed, astaxanthin is known for its ability to stabilize cell membranes and neutralize free radicals through its polyene chain, while capsaicin could potentially modulate the electronic state of astaxanthin's polyene chain

Abbreviations CALCOCO2: Calcium binding and coiled-coil domain-containing protein 2 DPP: Diabetes Prevention Program ECM: Extracellular matrix ER: Endoplasmic reticulum GLP-1: Glucagon-like peptide-1 GWAS: Genome-wide association studies HNF1A: Hepatocyte nuclear factor 1- IGT: Impaired glucose tolerance ITFG3: Integrin FG-GAP repeat containing 3 PE: Pancreatic elastase SIDD: Severe insulin-deficient diabetes TMAO: Trimethylamine N -oxide UPR: Unfolded protein response References Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

Li J-h, Chen Y, Ye Z-h, Chen L-p, Xu J-x, Han J et al (2024) Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis