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The inconsistency likely arises from differences in experimental conditions, such as pH, Cu+/Cu2+ ratio, A isoform, and the presence of reducing agents or cofactors (190)

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There is a vast amount of evidence that mitochondrial dysfunction occurs after the early cellular events in AD and can contribute to the advancement of further degeneration, but it is often unclear whether mitochondrial dysfunction is indeed just a secondary event or whether it might be involved in primary pathogenesis

[DOI] [PubMed] [Google Scholar] 547.Masse KE, Lu VB