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The term melasma derives from the Greek word for black, referring to its distinctive dark appearance that resembles cooked liverthough it has no connection to liver dysfunction

To further interrogate the specific pathways involved in the altered biological functions in metformin treated SW837 cells, Canonical Pathway Analysis was also performed on differentially expressed genes using IPA software

Hiyama et al

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The limitations of clinical endpoints further compound the problem

The inconsistent findings in our network meta-analysis may be due to the low number of trials ( n 9) included in that sensitivity analysis of participants with overweight and obesity