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Under normal conditions, free radical production is regulated

This is known as atrophic gastritis and results in ineffective transport and absorption of vitamin B12 from dietary sources[1]

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However, treatment of WT or Nox2-deficient BMDM with the global ROS scavenger N-acetyl-cysteine (NAC) or the flavoprotein inhibitor DPI (see Section 6 and Section 7) resulted in reduced total cellular ROS levels, reduced bacterial load and reduced induction of the Inositol-Requiring Enzyme 1 (IRE1), which is a sensor of endoplasmatic reticulum stress

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