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If any adverse reactions occur, discontinue use and consult a healthcare provider

rather, higher baseline bile acid levels correlate with slower atrophy, and a small randomized TUDCA study established safety and biologic target engagement without demonstrable clinical or imaging efficacy [208]

Gives the simplified mechanism and provides the information about naturally occurring peptides containing pyroglutamate

Unless otherwise specified, all reactions were performed in 20 mM Tris-HCl pH 8.0,150 mM NaCl buffer, with 25 M of freshly prepared Th-T (ThermoFisher Scientific) added to each reaction