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Local brain LPS administration, as well as astrocyte exposure to TNF and IL-1, depleted GSH ( Neuroinflammation in epilepsy is commonly associated with blood brain barrier (BBB) disruption, allowing infiltration of the brain parenchyma by peripheral immune cells and serum albumin as reviewed in detail by Van Vliet et al

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

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However, recent clinical evidence suggests the picture is more nuanced than previously understood

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Momtazmanesh et al., 2020), others report minimal or no significant effect (Magner et al., 2023