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A typical case is found in macrophages, where LPS inhibits NF-B signaling by inducing Inducible cAMP early repressor (ICER) expression via p38-mediated cAMP response element-binding protein (CREB), a negative feedback loop that is an important mechanism for preventing TLR-driven excessive inflammation

10.1016/j.intimp.2024.111657 19 AlrashdiJ.AlbasherG.AlanaziM

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Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion

Curr Mol Med 3, 56172.

This is a known limitation of using real-world EHR data, and our results should be interpreted with this context in mind