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In RLM, certain metabolites (Cit, Pyr and OAA) showed higher levels than in HepM and RHM, possibly due to the lower activity of Krebs cycle enzymes in RLM ( Figure 2 )

doi: 10.1016/j.freeradbiomed.2025.06.047, 112 ShiJ.GaoW.ShaoF

doi: 10.1021/acsami.1c07103 99 PandeyMChoudhuryHD/O Segar SinghSKChetty AnnanNBhattamisraSKGorainBet al

Metabolic dysfunction-associated steatohepatitis (MASH) is a more dangerous form of MASLD, characterized by histological findings of inflammation in the liver parenchyma, hepatocyte ballooning with increased hepatocyte necrosis, and an elevated risk of fibrosis progression [7]

N-acetylcysteine (NAC) suppresses mTOR activation by restoring glutathione levels and exhibits synergistic effects with rapamycin in reducing disease activity [68]

Cytometry (2004) 61B:359