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Early trials in the 2000s did not show meaningful weight loss versus placebo, and it never received FDA approval for that use

(2005) Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer

Median complete local pain response rates ranged from 80% [16] to 100% [19], with median local pain-free survival rates reaching 76.8% (IQR 55.383.8) at the longest follow-up [16]

Statements Author contributions YL: Writing review & editing, Writing original draft, Funding acquisition

The interaction of cells, ECM and biomechanical stress contributes to the homeostasis of the intervertebral disc