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Mitochondria contain 1015% of the intracellular GSH reaching a concentration of 1012 mM (54) while in the cytosol the concentration is 7 mM (54, 56)

The in vitro studies demonstrated that we designed liposome complex could penetrate faster and more specifically into AML cells, and trigger more efficiently the ROS elevation and GSH depletion thus result in AML cell apoptosis

Survivors and those presenting later in life develop progressive hematopoietic, neuroendocrine, and other systemic organ failure (Kearns-Sayre syndrome)

Research suggested that BPC-157 could ameliorate inflammation, reduce tissue damage, and improve clinical parameters in these models (Vuksic et al., 2007)

Furthermore, it seems that BPC 157 therapy might affect the effect of the lidocaine as whole

Such an approach can facilitate successful target discovery and clinical translation ( Figure 4 ), as discussed later in this section