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Dev Dyn 216(45):459468 Cai J, Zhu Q, Zheng K, Li H, Qi Y, Cao Q, Qiu M (2010) Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes

doi: 10.1016/j.cell.2021.06.028 73 HuYWenQCaiYLiuYMaWLiQet al

After attaining the peak level, glutathione concentrations declined progressively over time (Fig

Furthermore, the downregulation of proinflammatory cytokines, upregulation of the antioxidant SOD, and significant reductions in the expression of the iNOS and COX-2 proteins after activation of the NF-B and Nrf2 pathways were also observed in rats, confirming the effective therapeutic effects of perillyl alcohol [154] (Table 2)

Studies have also suggested that the antioxidant effects of aKG include reduced cataractogenesis in experimental animal models [152]

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