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The degeneration of neurons in the ventral tegmental area, accompanied by reduced dopamine release and impaired connectivity in target regions, is recognized as a key feature of the early stages of AD, preceding even the formation of A plaques

doi: 10.1016/j.ccr.2013.06.017

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However, iron overload in tissues, with specific accumulation in certain tissues as we age, is also true

Rineau, E., Gueguen, N., Procaccio, V., Genevive, F., Reynier, P., Henrion, D., et al

Prescribing an unapproved drug is fundamentally different