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10.1038/nature12111 Huo, J., Yu, Q., Zhang, Y., Liu, K., Hsiao, C.D., Jiang, Z., et al., 2019

Since both accumulation and complete elimination of BACE1/A adversely affect recovery after SCI, biological regulation of A or BACE1 levels after SCI by modulation of components of the UPS such as Fbx2-Uch-L1 via peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1alpha or gene expression (Gong et al., 2010, 2013b) may be a feasible strategy for the SCI treatment and AD (Figure 3)

Additionally, three of these investigations looked at IL-17 levels in lesional skin

doi: 10.1111/pcmr.12684 142 KimNHChoiSHLeeTRLeeCHLeeAY

Huang, T., Fang, L., He, R., Weng, H., Chen, X., Ye, Q., et al

Discussion The ability of bacterial populations or subpopulations of persister cells to survive high concentrations of bactericidal antibiotics for extended periods, despite lacking resistance mutations, is probably a major factor contributing to treatment failure 2,22,24,46,47,48,49