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251 LTB 4 binding to its receptor BLT1 triggers the activation of G proteins, which in turn stimulate a cascade of kinases responsible for the phosphorylation of downstream signaling proteins

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Although the initial reparative fibrosis is crucial for preventing rupture of the ventricular wall, an exaggerated fibrotic response and reactive fibrosis outside the infarct zone may lead to progressive impairment of cardiac function

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