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Glucose-6-phosphate isomerase (GPI) is closely related to RA activity (211) and a key enzyme involved in the Warburg effect of RA

This suggests an increasing burden and underrecognized trend of vitamin B12 deficiency can be an underlying cause of hospitalizations, particularly when left undiagnosed and untreated, possibly leading to severe medical conditions requiring inpatient care

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Vasisht B, Watson HK, Joseph E, Lionelli GT

Similarly, the reduced content of GSH and decreased activity of antioxidant enzymes in the intestine (decreased GR, GPx and SOD activity) (Reference Chen, Feng and Jiang34) and gills (decreased GR, GPx, SOD and CAT activity) (Reference Chen, Feng and Jiang35) of riboflavin-deficient fish have been reported