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They mapped out how each amino acid position influenced different properties: positions 3 and 7 might control binding affinity, while positions 5 and 12 determined membrane permeability, and positions 9 and 15 governed metabolic stability

In addition, chemical grafting to the 3 or 5 end can alter the tertiary structure of the aptamer which might be necessary for target binding

study (1998) compared four topical treatments on human skin over one month, with immunohistological analysis of skin biopsies (actual tissue samples examined under a microscope)

Science 310 (5751), 11931196

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