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Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

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[25] For ovulation induction in women, a single IM dose of 5,000 to 10,000 IU is administered after follicular maturation, usually 24 to 48 hours before scheduled ovulation or insemination

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Some might need injections every two weeks, while others might do fine with less frequent ones