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and 10 in congestive heart failure)

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The combined treatment demonstrated significantly greater efficacy than standard-dose pregabalin or acetyl-l-carnitine alone, in terms of both pain symptoms measured by improvement on the VAS score (+12.8%) and neurosensory symptoms measured by the DN4 tool (+22%)

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Furthermore, several clinical trials have also been conducted to confirm their possible efficacy, and multiple studies have confirmed that these antioxidants are critical to cancer therapy in alleviating CIPN without compromising the antitumor efficacy of chemotherapy