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Agmatine inhibits polyamine biosynthesis by binding to the enzyme ornithine decarboxylase and promoting its degradation

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In vivo retention of G/D-CuP and release of D-CuP To assess the spatiotemporal retention of G/D-CuP, it was topically applied to full-thickness dorsal wounds in diabetic mice

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Statistical Analysis Statistical analysis was performed by parametric one-way analysis of variance (ANOVA), with post-hoc NewmanKeuls test and non-parametric KruskalWallis test and subsequently the MannWhitney U test to compare groups

Secondly, metformins context-dependent regulation of autophagy and mitophagy remains an area of notable uncertainty