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When the content of ROS is too high and completely destroys the redox dynamic balance, lipid peroxidation will be induced by non-enzymatic and enzymatic pathways, and then result in ferroptosis (Su et al., 2019)

Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: Therapeutic implications

2011;7:e1002067

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[7] The discovery of this receptor class preceded the identification of ghrelin, its endogenous ligand, by several years

doi: 10.1007/s11655-022-3307-3