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Adderall may increase your heart rate and blood pressure to an unsafe level, potentially leading to stroke or other cardiac events

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[16] There is a particularly marked decline in sleep-related GH secretion, resulting in loss of the nocturnal pulsatile GH secretion seen in younger individuals and lack of a clear night-day GH rhythm

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"Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis" (PDF)