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All controls were individually matched to cases by age ( 1 year) at a 1:1 ratio

Whether coupling clip placement with other percutaneous procedures directed toward optimization of other anatomical abnormalities within the mitral apparatus (such as chordal replacement, altering ventricular, or atrial geometry among others) alters the disease course of severe MR remains to be studied and has potential to expand the patient pool that would benefit from such a combination procedure ( Proportionate vs

doi: 10.3389/fphar.2018.01354 67 ZhangYLiXHuangGWangHChenHSuYet al

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The results in arms in A and B were similar, with a later onset of action in arm A, which is expected for epigenetic regulators [49]

Arch Dis Child