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1 H NMR (700 MHz, D 2 O) : 4.35 (d, J = 14.5 Hz, 1H, H 7 ) 4.11 (d, J = 14.5 Hz, 1H, H 7 ), 3.32 (q, J = 5.9 Hz, 2H, H 5 ), 3.20-3.14 (m, 2H, H 2 ), 1.981.91 (m, 1H, H 3 ), 1.821.77 (m, 1H, H 4 ), 1.701.63 (m, 1H, H 4 ), 1.621.56 (m, 1H, H 3 )

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Thus A combinatorial strategy would very certainly be required [11]

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