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Trials reported once-weekly subcutaneous dosing, typically starting near 0.25 mg and escalating in ~4-week steps, with 2.4 mg as the most-studied maintenance example and up to 4.5 mg examined in dose-finding

doi: 10.1016/j.clon.2022.07.001

Peptide chains clump together into insoluble complexes that cannot be reversed by re-cooling

Wipe with alcohol, let it dry, then go straight in with the needle

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Oral semaglutide at doses of 25 and 50 mg were superior to a lower dose, 14 mg, in reducing hemoglobin A1c and body weight in adults with inadequately controlled type 2 diabetes in the PIONEER PLUS study [39]