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Stress & Cortisol Regulation Research indicates DSIP may modulate ACTH and cortisol secretion, helping explore hypothalamic-pituitary-adrenal (HPA) axis regulation [2]

Blood draw and plasma EV isolation Blood was collected after an overnight fast at four different timepoints throughout the study: (1) before first exercise training session, (2) immediately after first exercise training session, (3) before final exercise training session, and (4) immediately after final exercise training session

Broderick J, Palesch Y, Demchuk A, Yeatts S, Khatri P , Hill M, Jauch E, Jovin T, Yan B, Silver F, von Kummer R, Molina C, Demaerschalk B, Budzik R, Clark W, Zaidat O, Malisch T, Goyal M, Schonewille W, Mazighi M, Engelter S, Anderson C, Spilker J, Carrozzella J, Ryckborst K, Janis L, Martin R, Foster L, Tomsick T

Sortilin is an intracellular chaperone that binds to the prodomain of BDNF to traffic it to the regulated secretory pathway