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Lack of critical involvement of caspase-3 in eryptosis has been emphasized in an extensive analysis of the caspase-3 contribution to eryptosis, which has revealed that eryptosis triggered in vitro by diverse compounds is not associated with caspase-3 recruitment in the majority of cases [84]

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Resveratrol activates Caspase-3 and Caspase-8, and up-regulates the protein expression of Bax [851,852,853], while inhibiting anti-apoptotic proteins like Bcl-2 [854], in order to induce apoptosis in luminal squamous cell carcinoma, cervical carcinoma, colon carcinoma, ovarian carcinoma, and uterine leiomyoma cells

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Molecular Mechanisms of Enzyme Activation by Monovalent Cations