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Research Overview: Triple-Pathway Receptor Signaling Crosstalk The primary investigative utility of this triple-peptide blend centers on its ability to mimic and maximize natural growth hormone (GH) pulse amplitudes by simultaneously targeting separate regulatory mechanisms in pituitary somatotrophs

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10.1016/j.bbrc.2019.02.142 Summary Keywords diabetic wound, inflammatory response, mitochondrial dysfunction, mtDNA leakage, NLRP3 inflammasome, oxidative stress Citation Chen Y, Li H and He W (2026) Mitochondria-mediated inflammation and diabetic wound healing: mechanisms and therapeutic strategies

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311 Metformin can also mitigate age-related hearing loss and neurodegeneration symptoms in D-galactose-induced aging rats by modulating the AMPK/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway