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, VHL deletion) or reactive oxygen species (ROS) under normoxia, compounded by tumor vascular abnormalities inducing regional hypoxia ( Figure 1 )

The administration of these agents significantly reduces the B cell population and suppresses autoantibody production (110)

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The resulting vcf file was then filtered using vcftools 53 to retain loci where all six colonies had at least 10 coverage, with a minimum quality score of 30

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Another important outcome was represented by a significant upregulation of genes linked to axonal growth, to the cAMP signaling pathway, and to myelin function