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In a previous report, Kudo and colleagues demonstrated that only meningiomas exhibit extremely high GSH levels, in contrast to other forms of brain tumors, such as GBM, gliomas, germinoma, multiple myeloma, and small-cell carcinoma [45]

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Consistent with this pattern, the OMe derivative 9 had activity that was similar to 1 and more potent than 2 , while placement of the OMe group at the ortho position 10 eliminated activity

Both mouse primary cortical neurons (10 or 20 M for 3 or 6 h) and a triple-transgenic AD mouse model treated with SF (56.4 or 282 mol/kg/day for 6 days/week for 8 weeks) exhibited enhanced brain-derived neurotropic factor (BDNF) expression, crucial for neuronal survival and synaptic plasticity, suggesting a potential epigenetic mechanism for SFs neuroprotective effects (61)