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Therefore, these effects are not only local, but the microenvironment that is created maintains M1 activation leading to further, widespread damage

511 Zimdahl Kahlin A, Helander S, Wennerstrand P, Vikingsson S, Mrtensson LG, Appell ML (2021) Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism