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Table 2 Application of various mechanical stimuli on synovial fibroblasts, including types of forces, application methods, time intervals, and observed effects

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Ma and Li, 2018), Trimethylamine N-oxide (TMAO), an important gut microbe-dependent metabolite, is generated from dietary choline, betaine and L-carnitine which are metabolized to trimethylamine (TMA) through gut microbiota metabolism and further converted to TMAO by hepatic flavin monooxygenases (FMOs) (Lang et al., 1998