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It has also been demonstrated to impair the uptake of essential amino acids by the transporter protein SLC38A2, thereby decreasing the cellular levels of these nutrients [175]

Secondly, necroptosis can release inflammatory factors, such as IL-1 and TNF-, activate microglia and astrocytes, trigger neuroinflammatory responses, and further damage the function and survival of neurons

161 In addition, Cu directly binds to MEK1 with high affinity, which in turn promotes tumor growth by activating downstream ERK1/2 phosphorylation

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Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL

N Engl.J Med 7-24-1997;337(4):230-236