glutathione gbm6 patient derived xenograft Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival Combined inhibition of de novo – Catabolism of extracellular glutathione supplies
Catabolism of extracellular glutathione supplies cysteine to support tumours Nature Oxidative Stress and Antioxidants in Glioblastoma: Mechanisms of Action, Therapeutic Effects and Future Directions Patient Derived Glioma Models: From Patients to Dish to Animals Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma: Cell Reports Patientderived xenograft models in pancancer: From bench to clinic Li 2025 Interdisciplinary Medicine Wiley Online Library Frontiers Successes and challenges in modeling heterogeneous BRAFV600E mutated central nervous system neoplasms
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