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the data is incomplete or there are significant methodological deficiencies (such as insufficient sample size and no statistical analysis).Then, using specific data collection forms, the researchers extracted relevant data from each study, including basic information about the article (first author, year of publication, journal name, and type of study)

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10.1186/s13072-018-0217-x 2 AhluwaliaB.MoraesL.MagnussonM

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Later, another study showed that a Parthenolide (PTL)-derived drug DMOCPTL directly bound to the GPX4 active site (selenocysteine 46), and led to GPX4 ubiquitination in triple-negative breast cancer cells ( Discovering the E3 ligase is also very important for understanding the regulatory mechanisms of protein ubiquitination