glutathione redox regulation of the homeostasis by (GSH), thioredoxin Frontiers | Glutathione-the “master” antioxidant

Pallett LJ, Dimeloe S, Sinclair LV, Byrne AJ, Schurich A

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elegans exhibits significant metabolic plasticity, in which the modulation of lipid stores effectively accommodates energetic demand during periods of nutrient stress and subsequent recovery

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This methylation inhibits transcription factor binding and converts chromatin into a more condensed, transcriptionally inactive state, leading to FMRP deficiency and the manifestation of FXS symptoms (216)

In the event of GLS or ASNS inhibition, compensatory mechanisms may emerge, potentially accounting for the diminished anticancer efficacy observed in GLS targeting