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B12 also plays a significant role in preventing vascular and cognitive diseases through its involvement in the conversion of homocysteine to methionine and then to Sadenosylmethionine

4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Gao et al., 2021)

Metabolic studies showed that AOD9604-treated animals had increased lipolytic rates measured in isolated adipocytes, elevated circulating free fatty acid levels, and enhanced fatty acid oxidation rates